Which disease is characterized by obesity and a "moon face"?

Cushing's disease is characterized by obesity and a "moon face," which refers to the roundness and fullness of the face that can occur due to the overproduction of cortisol. This condition, caused by various factors such as tumors on the adrenal glands or pituitary gland, leads to an accumulation of fat in specific areas of the body, including the face, creating a distinct appearance.

In Cushing's disease, the increased cortisol levels not only contribute to obesity but also affect the distribution of fat, leading to the characteristic physical changes associated with the condition. The "moon face" appearance is a hallmark symptom that helps differentiate Cushing's from other disorders that may involve weight gain.

Other choices do not present the same combination of obesity and facial features. Hypothyroidism can lead to weight gain, but it does not typically cause a moon face. Acromegaly involves excessive growth hormone but is more associated with enlargement of bones and tissues rather than a round face. Diabetes mellitus can lead to weight changes but is not characterized specifically by the appearance of a moon face.