What is a characteristic of Cushing's disease?

Central obesity is a characteristic feature of Cushing's disease. This condition, caused by an overproduction of cortisol, leads to a redistribution of body fat. Patients often exhibit an increase in fat accumulation particularly around the abdomen and face, resulting in a rounded facial appearance commonly referred to as a "moon face." The fat distribution can also lead to a "buffalo hump," which is a noticeable accumulation of fat between the shoulder blades.

In contrast, while muscle wasting can occur in Cushing's disease, it is not the most defining characteristic. Other consequences, such as excessive sweating and altered skin pigmentation, do occur in some patients but are less specific and less reliable as a hallmark feature of the disease. Central obesity remains one of the most prominent and easily identifiable manifestations, making it a key characteristic of Cushing's disease.